&FCP fcp_mu | fcp_dynamics | fcp_conv_thr | fcp_ndiis | fcp_mass | fcp_velocity | fcp_temperature | fcp_tempw | fcp_tolp | fcp_delta_t | fcp_nraise | freeze_all_atoms &CELL cell_dynamics | press | wmass | cell_factor | press_conv_thr | cell_dofree &IONS ion_positions | ion_velocities | ion_dynamics | pot_extrapolation | wfc_extrapolation | remove_rigid_rot | ion_temperature | tempw | tolp | delta_t | nraise | refold_pos | upscale | bfgs_ndim | trust_radius_max | trust_radius_min | trust_radius_ini | w_1 | w_2 | fire_alpha_init | fire_falpha | fire_nmin | fire_f_inc | fire_f_dec | fire_dtmax &ELECTRONS electron_maxstep | exx_maxstep | scf_must_converge | conv_thr | adaptive_thr | conv_thr_init | conv_thr_multi | mixing_mode | mixing_beta | mixing_ndim | mixing_fixed_ns | diagonalization | diago_thr_init | diago_cg_maxiter | diago_ppcg_maxiter | diago_david_ndim | diago_rmm_ndim | diago_rmm_conv | diago_gs_nblock | diago_full_acc | efield | efield_cart | efield_phase | startingpot | startingwfc | tqr | real_space &SYSTEM ibrav | celldm | A | B | C | cosAB | cosAC | cosBC | nat | ntyp | nbnd | nbnd_cond | tot_charge | starting_charge | tot_magnetization | starting_magnetization | ecutwfc | ecutrho | ecutfock | nr1 | nr2 | nr3 | nr1s | nr2s | nr3s | nosym | nosym_evc | noinv | no_t_rev | force_symmorphic | use_all_frac | occupations | one_atom_occupations | starting_spin_angle | degauss_cond | nelec_cond | degauss | smearing | nspin | sic_gamma | pol_type | sic_energy | sci_vb | sci_cb | noncolin | ecfixed | qcutz | q2sigma | input_dft | ace | exx_fraction | screening_parameter | exxdiv_treatment | x_gamma_extrapolation | ecutvcut | nqx1 | nqx2 | nqx3 | localization_thr | Hubbard_occ | Hubbard_alpha | Hubbard_beta | starting_ns_eigenvalue | dmft | dmft_prefix | ensemble_energies | edir | emaxpos | eopreg | eamp | angle1 | angle2 | lforcet | constrained_magnetization | fixed_magnetization | lambda | report | lspinorb | assume_isolated | esm_bc | esm_w | esm_efield | esm_nfit | lgcscf | gcscf_mu | gcscf_conv_thr | gcscf_beta | vdw_corr | london | london_s6 | london_c6 | london_rvdw | london_rcut | dftd3_version | dftd3_threebody | ts_vdw_econv_thr | ts_vdw_isolated | xdm | xdm_a1 | xdm_a2 | space_group | uniqueb | origin_choice | rhombohedral | zgate | relaxz | block | block_1 | block_2 | block_height | nextffield &CONTROL calculation | title | verbosity | restart_mode | wf_collect | nstep | iprint | tstress | tprnfor | dt | outdir | wfcdir | prefix | lkpoint_dir | max_seconds | etot_conv_thr | forc_conv_thr | disk_io | pseudo_dir | tefield | dipfield | lelfield | nberrycyc | lorbm | lberry | gdir | nppstr | gate | twochem | lfcp | trism Pw.x / PWscf / Quantum ESPRESSO (version: 7.2) Pw.x: input description Input File Description Program:
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Metformin is a synthetic biguanide (two coupled molecules of guanidine) that is mainly absorbed in the upper small intestine and exhibits flip–flop pharmacokinetics with limited oral bioavailability 19, 20. However, reassuring data were provided in a long-term follow-up study showing similar anthropometrics in children exposed or not to metformin in utero 18. While in utero exposure to metformin was considered safe, some studies have found higher occurrence of small for gestational age birthweight and increased risk of childhood obesity 17. As metformin crosses the placenta and circulates in the developing fetus, the long-term effects of fetal exposure to metformin have raised concerns about the potential risk to growth and development of the fetus, and later, on offspring health 16. It is important to note that metformin is increasingly being used during pregnancy for the management of gestational diabetes mellitus and in those with polycystic ovary syndrome or T2DM 15. Administered orally as an immediate-release or extended-release formulation, the usual dose of metformin (0.5–2.5 g daily) is effective for long-term glycaemic control, with notable changes in HbA 1c from baseline 1, 2. Metformin is now used daily by >200 million patients with T2DM worldwide as monotherapy or in combination with sulfonylureas or dipeptidyl peptidase 4 inhibitors 1, 2. In addition, metformin moderately reduces body weight gain, possibly through upregulation of the anorectic cytokine growth differentiation factor 15 (refs. The benefits of metformin therapy in T2DM have been well documented it has long-term safety and efficacy data, low risk of hypoglycaemia, cardiovascular benefits, mortality benefits, additive or synergistic effects in combination therapy, low cost and wide availability 1, 2, 10, 11, 12. In 1957, the French physician Jean Sterne introduced the clinical use of metformin for the treatment of adult-onset diabetes mellitus 3, 4. Interestingly, in the past few years, the use of metformin has been explored for the management of patients with T2DM and obesity who contract influenza 6 or COVID-19 (refs. In 1949, metformin (called flumamine at that time) was used for the treatment of an epidemic influenza outbreak in the Philippines and was noted to lower blood levels of glucose in some of the patients with influenza 5. Metformin was first synthesized in 1922, and the first report of it being used to lower blood levels of glucose (in rabbits) was published in 1929 (refs. In this Review, we highlight the latest advances in our understanding of the mechanisms of action of metformin and discuss potential emerging novel therapeutic uses.įor the past 60 years, metformin (1,1-dimethylbiguanide hydrochloride) has been the most commonly used glucose-lowering agent and has become the first-line medication for individuals newly diagnosed with type 2 diabetes mellitus (T2DM) in many clinical guidelines 1, 2. Based on the efficacy and safety records in T2DM, attention has been given to the repurposing of metformin as part of adjunct therapy for the treatment of cancer, age-related diseases, inflammatory diseases and COVID-19. Initial studies have shown that metformin targets hepatic mitochondria however, the identification of a novel target at low concentrations of metformin at the lysosome surface might reveal a new mechanism of action. At the molecular level, it seems that the mechanisms of action vary depending on the dose of metformin used and duration of treatment. However, increasing evidence points towards other sites of action that might also have an important role, including the gastrointestinal tract, the gut microbial communities and the tissue-resident immune cells. Early evidence highlighted the liver as the major organ involved in the effect of metformin on reducing blood levels of glucose. Surprisingly, the mechanisms underlying its therapeutic action are complex and are still not fully understood. Currently, metformin is the first-line medication to treat type 2 diabetes mellitus (T2DM) in most guidelines and is used daily by >200 million patients. Since then we have seen hundreds of thousands of students with disabilities improve their learning by being able to study better from class. By 2007, Sonocent Audio Notetaker had been born. Also, in 2021, Sonocent officially changed the company's name to Glean and will cease to support Sonocent Audio Notetaker. Back in 2005, Dr Roger Tucker had an idea for a piece of software to help dyslexic learners study from their audio recordings. UM’s license for Sonocent Audio Notetaker expired on July 1st, 2021 thus, Sonocent is no longer available. With multiple smartphones and AI patent-pending approach - we boost audio quality and provide meeting notes in a way a conversation goes. We believe that one needs usable meeting notes to create a meeting summary. If students lose account access, contact the Office for Disability Equity, and make another request. Reason8 provides the best automated note-taking quality on the market for in-person meetings. When all licenses are distributed, inactive accounts will be assigned to other students. The number of licenses for Glean is limited. Student's audio notes will be available for 90-days after account deactivation.Īdditionally, students must make a new request for the next semester by contacting their Office for Disability Equity Access Consultant. Upon required completion, an invitation from Glean will be sent via their student email with account setup instructions and how to access the note-taking program.Īt the end of each semester, all Glean accounts will be deactivated. Upon approval for Glean usage, the Assistive Technology Specialist will send a link to a request form asking a few questions. To request access to Glean, students must contact the Office for Disability Equity. Now, as Glean, we've taken everything we've learned from assistive technology and made the learning process more inclusive for students of all abilities. Middle Tennessee State Universitys Adaptive Technology Center is pleased to offer Sonocents Audio Notetaker software to qualifying students enrolled with. Please watch these YouTube videos to learn more about Glean and view full software tutorials. We originally created Sonocent Audio Notetaker to provide accessible audio notes for people who found working with text notes difficult. (Transcript quality is based on the quality of the recording) Glean also provides a transcription of the lecture audio if required. Audio Notetaker only works with Mac and Windows - Glean now gives you more choice for devices with Mac, Windows, iOS, Android and Chromebook compatibility. There are many ways to take notes with Glean. Compare price, features, and reviews of the software side-by-side to make the best choice for your business. Sonocent Audio Notetaker using this comparison chart. Glean records the audio in class or online while the student types notes or flags lecture content. Claim Sonocent Audio Notetaker and update features and information. Glean Notetaker is a cloud-based software for students with a note-taking accommodation approved by the Office for Disability Equity. "What I remember vividly was a shot of the actor re-enactment of someone standing in a kitchen, and their back/shoulders caught fire and they ripped their clothing off in a frenzy," Cordell told VICE in an email. It was the example of Kay Fletcher- who claimed that in 1996, while having a peaceful morning at home, smoke and the smell of burnt flesh began to emanate from her body-that terrified Laine Cordell, an executive assistant who spent her sick days as a tween curled up with Unsolved Mysteries marathons. It’s kind of like quicksand-as a kid, I always thought quicksand was going to be more of a problem than it actually is." I even remember there’d be times that I’d feel my forehead to make sure I wasn’t feeling hot because I was afraid I would overheat and combust. "Up until I was about 14 or 15, I thought I was going to turn to ashes out of nowhere. With fire as her biggest fear, Lopez thought of spontaneous human combustion as a particularly terrible way to go, she said. I can still see it so clearly!" she told VICE in an email. "The ashes looked as though they belonged to somebody who was laying on the bed. Naissa Lopez, a communications director who recalled watching reruns of Unsolved Mysteries at night on Lifetime when she was around 10, had similar takeaways from the Mott scene. That bedroom scene is stuck in my memory forever." The bedding is red so in my mind it looked like blood, even though there wasn’t any blood in the shot, and then the way just that part of the room is burned but everything else is untouched is creepy. "In the episode, they show the bed where someone died from fire, and the room just looks so strange that it really sticks out. Though she started watching the show around 1990 at the age of 10 or 11 and loyally watched its reruns, the spontaneous combustion segment is easily the one that frightened her the most. "When anyone mentions Unsolved Mysteries, two things come to my mind: the theme song and spontaneous combustion," Brennan told VICE in an email. Detailing the experience of Kendal Mott, for example, Stack narrated a re-enactment of a man finding his father's charred remains in bed: "Fire had reduced his father to a scattering of ashes, a few splinters of bone, and a fragment of skull." Even compared to segments about murders and supernatural events, Unsolved Mysteries' spontaneous combustion segment left a fear-inducing and indelible mark on impressionable youths in the visual form of a burned bed, a walker next to a grisly piece of a leg, and a woman caught in a cloud of smoke.įor Jessica Brennan, the co-host of the California True Crime podcast, the images associated with the Mott example have stuck with her ever since. Through a series of re-enactments and interviews with alleged witnesses of spontaneous human combustion, a skeptic, and a supporter, the episode explored examples of-and made cases for and against-the idea that a human body could light itself on fire from the inside out. "Students of the paranormal call it spontaneous human combustion, or 'SHC,' when a perfectly normal person bursts into flame without warning and without apparent cause," Stack said. In one particularly memorable episode from its ninth season, which first aired in 1997 and also covered the murder of Tupac Shakur and the hunt for home invaders in Ohio, the deep-voiced host Robert Stack introduced the idea of spontaneous human combustion to the show's vast audience. Many of us with this particular horror can thank Unsolved Mysteries, the true crime documentary show that bounced around networks from 1987 to 2010, and which has found a new home on Netflix in a series reboot that launched yesterday. It was a win for Coach Odom, but also for all those who helped shape and inform Tim Duncan’s college experience as a student-athlete: former professors, coaches, teammates, trainers, team doctors, cafeteria staff, office staff, equipment managers, athletic department, Screamin’ Demons, custodians, and academic advisors. This night couldn’t get any better for a coach I would think. Coach did a great job and assured Spurs Nation that there is another community that loves Tim just as much as they do!Ĭoach Dave Odom (WFU) 7 consecutive NCAA appearancesĬoach went on to describe his first phone call with Tim and, then another, with Greg Popovich four years later, both of which changed the trajectory of Wake Forest and Spurs basketball respectively. With three kids now under 6 and living in San Antonio, I sometimes feel farther from Wake Forest than I’d like to, but as I listened to my former coach (freshman year), Dave Odom, remind 18,000 people of how all of this began with Tim, I felt close to Winston-Salem. Intuitively, Duncan knew how to encourage the person that needed encouraging. It was Tim, “let’s go to dinner man.” Manu said they talked about everything but basketball and it was exactly what he needed. Shortly thereafter, he heard another ring and quickly realized that there was also a phone in the bathroom. Manu was devastated and after receiving several phone calls in his hotel room that night, he decided to unplug the phone next to his bed as he didn’t want to talk to anyone. At one point during the playoffs several years ago, a Ginobili end of game turnover against Sacramento led to a Spurs loss. Manu Ginobili shared one of his most impactful moments with Tim. In a video, Bruce Bowen described Tim’s unique ability to take joy in other people’s success as he recalled the genuine excitement that Duncan had when Kawhi Leonard received MVP honors during their most recent championship run. Knowing the curve that Boban needed to get through to improve, Tim quickly replaced the intern and went on to play one-on-one for 20 minutes – the only catch was that Tim (at age 40) played defense the whole time. Sunday night, I felt like I was at a rehearsal dinner enjoying the gift of story without the pressure of having to speak.Īt one point during the night, Tony Parker described a moment where Tim walked through the gym and saw an intern rebounding for Boban Marjonobic, a 7 foot rookie center from Serbia. There was no vagueness, no generalities about character – only authentic recollections of a real person. The testimonies shared and speeches made were not about coach / player speak that you often hear in a typical interview in sports. It was about celebrating the effectiveness of one leader and his relentless pursuit to be the kind of teammate that his teammates needed him to be. It was about a coach who loved his player. It was about an organization where individuals get over themselves. As it turned out, this night was about relationships that have endured over a long period of time. As I watched alongside my Dad and six-year old son, I recognized that the reveal of the #21 jersey in the rafters was really a sideshow. At that point, the former All-American and, then NBA All-Star, looked at me and said, “What’s up?” I said, “Hey man” and then decided to tie my shoes some more.įast forward 16 years later, Tim Duncan’s jersey retirement ceremony was one of the more meaningful moments that I’ve experienced in sports. As I diligently tied my shoes against the wall, Tim sat down beside me to put on his shoes - he was back in Winston-Salem for a visit and decided to workout with our team. In the summer of 2000, I showed up for one of my first pick-up games as a walk-on at Wake Forest. Reflections from #21’s Jersey Retirement Ceremony: a tribute to the ultimate teammate H&R Block’s Online Assist feature offers additional virtual support with live assistance and screen-sharing, and can also be purchased on top of any of the plans starting at $70. The decision on which tier is best for you depends mostly on the deductions and tax credits you want to claim.įree basic audit support is offered with all H&R Block tax plans, and enhanced “Worry-Free Audit Support,” including IRS communication and in-person audit representation, can be added to any plan for $19.99. The company is offering promotional prices temporarily, lowering the costs to $85 or less. H&R Block offers four different online products - Free Online, Deluxe, Premium and Self-Employed - which range from $0 to $110. ( Jackson Hewitt, for instance, offers unlimited state returns, plus your federal return for $25.) What are H&R Block’s different products? If you’re filing multiple state returns, you might want to look elsewhere. We recommend students and other filers looking for free tax software consider H&R Block, as well as taxpayers who’d like the option of making an in-person appointment with a tax preparation professional. What separates H&R Block is the robustness of its free offering and the ability to get assistance in-person at a physical H&R Block office. Much like TurboTax, H&R Block Online offers a range of tax-preparation software services that can cover most income tax situations. The help screens and extra information are useful, if sometimes not easy to find. Though not quite as smooth as TurboTax, H&R Block Online employs a well-designed, interview-style system to guide you through your tax return and eliminate potential errors. Those additions make H&R Block’s free plan an attractive choice for filers like students who don’t have complicated tax situations but want to claim certain important deductions and tax credits.Ī spare, simple interface and questionnaire-style process make H&R Block Online easy to use. What separates H&R Block from TurboTax is a free version that allows several more forms including Form 1040 Schedule 1 - which includes unemployment compensation, deductions for student loan interest and more - as well as free support for the child tax credit, earned income tax credit and education credits. H&R Block offers four primary tiers of service - Free Online, Deluxe, Premium and Self-Employed - with options to add online tax support. It wasn’t quite enough to earn our designation of best tax software overall, but it comes darn close. H&R Block’s 2023 tax software includes a well-polished interface, strong support features and a free plan that provides better coverage than TurboTax. Online Assist doesn’t guarantee help from a CPA. A group of coronaviruses that share the same inherited set of distinctive mutations is called a variant. number of care homes with a suspected case of COVID-19 number of. An outbreak of novel coronavirus (2019-nCoV) that began in Wuhan, China, has spread rapidly, with cases now confirmed in multiple countries. Follow new cases found each day and the number of cases and deaths in Minnesota. We use cookies to collect anonymous data to help us improve your site browsing experience. Weekly Trends - Graphs - Countries - News. Coronavirus Population COVID-19 Coronavirus Pandemic. Historical data with cumulative charts, graphs, and updates. Scientists can track mutations as they are passed down through a lineage, a branch of the coronavirus family tree. From cities to rural towns, stay informed on where COVID-19 is spreading to understand how it could affect families, commerce, and travel. Daily and weekly updated statistics tracking the number of COVID-19 cases, recovered, and deaths. When an infected human cell assembles new coronaviruses, it occasionally makes tiny copying errors called mutations. May help the virus bind more tightly to cells.Īppears in several lineages, including B.1.617.2 (Delta). Coronavirus Population World / Countries / Pakistan. May help the virus avoid some kinds of antibodies.Īppears in several lineages, including B.1.351 (Beta) and P.1 (Gamma). Minnesota COVID-19 Coronavirus update by county with statistics and graphs: total and new cases, deaths per day, current active cases, recoveries, historical data, trends, projections, and timeline. Pakistan Coronavirus update with statistics and graphs: total and new cases, deaths per day, mortality and recovery rates, current active cases, recoveries, trends and timeline. As of 2 June 2023, a total of 668,882,018 vaccine doses have been administered. Florida COVID-19 Coronavirus update by county with statistics and graphs: total and new cases, deaths per day, current active cases, recoveries, historical data, trends, projections, and timeline. Helps the virus bind more tightly to human cells.Īppears in several lineages. In United States of America, from 3 January 2020 to 5:57pm CEST, 25 October 2023, there have been 103,436,829 confirmed cases of COVID-19 with 1,136,920 deaths, reported to WHO. Mutations that may help the coronavirus spreadĪppeared in early 2020 and spread around the world.Ī defining mutation in several lineages, including B.1.1.7 (Alpha), B.1.351 (Beta) and P.1 (Gamma). Within a month it was dominant in the U.S.Įmerged in India in late 2020 and spread around the world.ĭelta carries the L452R spike mutation, among others. Alternatively, you can set the date and time to count till (or from) the event. Set the hour, minute, and second for the online countdown timer, and start it. The timer will appear, and the pre-selected sound will be played. Its often quicker (around 5 to 12 hours), in. Alternatively, you can set the date and time to count days, hours, minutes, and seconds from our set timer online tool. In a 1st pregnancy, the time from the start of established labour to being fully dilated is usually 8 to 18 hours. In certain countries, 24-hour time is referred to as military time, since this is the time format used by militaries (and other entities) around the world, where unambiguous time measurement is particularly important. It is a free and easy-to-use countdown timer. Choose the time you want the online countdown timer to start counting down. The hours from 0-11 denote what would be the AM hours on a 12-hour clock, while hours 12-23 denote the PM hours of a 12-hour clock. This time format is an international standard, and is often used to avoid the ambiguity resulting from the use of a 12-hour clock. Using the terms "12 midnight" and "12 noon" can remove ambiguity in cases where a person may not be accustomed to conventions.Ī 24-hour clock typically uses the numbers 0-23, where 00:00 indicates midnight, and a day runs from midnight to midnight over the course of 24 hours. On digital clocks and watches, "AM" stands for ante meridiem, meaning "before midday," while "PM" stands for post meridiem, or "after noon." By convention, 12 AM denotes midnight, while 12 PM denotes noon. Depending on the clock being used, most analog clocks or watches may not include an indication of whether the time is in the morning or evening. This 12 Minute Timer is very easy to start, just click the Start button and go about your business. Most people read time using either a 12-hour clock or a 24-hour clock.Ī 12-hour clock uses the numbers 1-12. There are a lot of ways it can go wrong, though. Related Time Card Calculator | Time CalculatorĪn hour is most commonly defined as a period of time equal to 60 minutes, where a minute is equal to 60 seconds, and a second has a rigorous scientific definition. Twelve Minutes gives you about 10 minutes (if you’re lucky) per loop to learn something new and progress toward solving the mystery. The video below might help you with that process to get a detailed overview.ĭespite that, transferring large files will take up a lot of your internet bandwidth, and also the transfer speeds depend upon your internet speed. All you’d need to do is select the file/folder and share it using Bluetooth. It “almost” works like Airdrop on Android. It’s obvious, but you can easily transfer files from Android to Mac using Bluetooth. So here are the best wireless ways to transfer files from Android to Mac. However, the wireless methods are quite slow compared to the USB method since there’s nothing like Airdrop that can transfer files from Android to Mac as Apple does within the ecosystem. Other Ways to Perform Android to Mac File TransferĪpart from the wired way, you can use transfer files from Android to Mac using wireless methods. From the Android File Transfer app, you can drag and drop the files that you want to copy to your Mac.If it hasn’t poped up, change the transfer mode to File Transfer or MTP mode on your Androif phone. The Android File Transfer will launch automatically. Now connect your Android phone to the Mac via USB Cable.You’ll be prompted with a message as a securtiy check since the application was dowloaded from the internet.Open Android File Transfer from the Launchpad or the Applications folder in the Finder.Drag and drop the Android File Transfer app to the Applications folder when a Finder window pops up.Open the AndroidFileTransfer.dmg file that you downloaded previously.Download Android File Transfer from the Official Android website. Reduce PDF Size with iLovePDF Compress AlternativeĪfter a more detailed understanding of the online software, are you thinking of finding an alternative to iLovePDF to resize PDF files? SwifDoo PDF enables you to compress PDFs by customizing the quality and resolution except for the available compressing options. PDF converting feature has limited options.No translating tool to translate a PDF to any other language.Online sites always have the risk of information leakage.
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